Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Are environmental factors important in primary systemic vasculitis? A case-control study.

Suzanne E Lane1, Richard A Watts, Graham Bentham

  • 1Norfolk and Norwich University Hospital, Norwich, UK. LANE@suzanne-e.fsnet.co.uk

Arthritis and Rheumatism
|March 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changing incidence and serotype trends in ANCA-associated vasculitis: a 30-year population-based study in Norfolk, UK.

Rheumatology (Oxford, England)·2026
Same author

Cutaneous Manifestations of Vasculitis: A Cross-Sectional Analysis From an International Cohort.

International journal of dermatology·2026
Same author

Performance in adults of the EULAR/PRINTO/PRES (Ankara 2008) classification criteria for IgA vasculitis.

RMD open·2025
Same author

Idiopathic polyarteritis nodosa - does it still exist? Viewpoint 1: as our knowledge makes progress, idiopathic polyarteritis nodosa is fading away.

Rheumatology (Oxford, England)·2025
Same author

Stroke frequency, associated factors, and clinical features in primary systemic vasculitis: a multicentric observational study.

Journal of neurology·2024
Same author

Classification and epidemiology of vasculitis: Emerging concepts.

Best practice & research. Clinical rheumatology·2023

Farming and occupational exposures to silica and solvents are linked to primary systemic vasculitis (PSV). Allergy also showed a significant association with PSV development.

Area of Science:

  • Environmental epidemiology
  • Rheumatology
  • Occupational health

Background:

  • Primary systemic vasculitis (PSV) encompasses a group of rare autoimmune diseases.
  • The etiology of PSV is not fully understood, with potential environmental triggers under investigation.

Purpose of the Study:

  • To investigate the association between primary systemic vasculitis (PSV) and various environmental risk factors.
  • To identify potential occupational and lifestyle exposures linked to PSV development.

Main Methods:

  • A case-control study involving 75 PSV patients and 273 controls was conducted.
  • Data on occupational history, environmental exposures, allergies, and medical history were collected via structured interviews.
  • Statistical analysis, including stepwise multiple logistic regression, was used to determine odds ratios (OR) and 95% confidence intervals (95% CI).

Related Experiment Videos

Main Results:

  • Farming exposure in the year prior to symptom onset was significantly associated with PSV (OR 2.3).
  • Occupational exposure to silica and solvents showed significant associations with PSV, particularly in the index year.
  • Drug allergy and overall allergy were also significantly associated with PSV (OR 3.6 and 2.2, respectively).

Conclusions:

  • This study identifies farming as a novel environmental risk factor associated with primary systemic vasculitis.
  • The findings support previously suggested links between PSV and occupational exposures to silica, solvents, and allergies.