[Preoperative bifidum-lactobacterin therapy in children with cleft lip and palate]

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S M Murtazaev, A Iu Iuldashev, M I Azimov

    Stomatologiia
    |March 14, 2003
    PubMed

    Insights

    Early use of eubiotics (bifidumbacterium and lactobacterium) can improve intestinal microflora and immunity in children with congenital cleft lip and palate. This intervention may reduce complications before and after surgery.

    Area of Science:

    • Pediatric medicine
    • Microbiology
    • Immunology

    Context:

    • Investigated 125 children with congenital cleft lip and palate.
    • Focused on microbiological and immunologic parameters of peripheral blood.

    Purpose:

    • To determine the role of early eubiotic correction in pediatric patients with congenital cleft lip and palate.
    • To assess the impact of eubiotics on intestinal microflora and immune restoration.

    Summary:

    • Early administration of eubiotics (Bifidumbacterium and Lactobacillus) for 8-9 months prior to surgical repair (chiloplasty and uranoplasty) was studied.
    • Eubiotic treatment normalized intestinal microflora, leading to restored cellular and humoral immunity.
    • Observed a decrease in both accompanying and postoperative complications.

    Impact:

    • Highlights the positive role of early eubiotic intervention in managing children with congenital cleft lip and palate.
    • Suggests a potential strategy to improve surgical outcomes and reduce complications in this patient group.
    • Underscores the gut-immune axis connection in pediatric surgical care.

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