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Published on: July 17, 2020
Preparation of the 4-hydroxytryptamine scaffold via palladium-catalyzed cyclization: a practical and versatile
Nicholas Gathergood1, Peter J Scammells
1Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Organic Letters
|March 14, 2003
Abstract:
[reaction: see text] The 4-hydroxytryptamine scaffold of psilocin was successfully prepared via palladium-catalyzed cyclization of protected N-tert-butoxycarbonyl-2-iodo-3-methoxyaniline and an appropriately substituted silyl acetylene. Removal of the protecting groups afforded psilocin in good yield.

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