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Intracranial chloroma in hypereosinophilic myelofibrosis
Sharon W W Chan1, N N Datta, Teresa M M Thomas
1Department of Surgery, United Christian Hospital, Room 5C, Block G, Hip Wo Street, Kwun Tong, Hong Kong Special Administrative Region (HKSAR), China.
Background:
Chloroma, also called granulocytic sarcoma, is a localized extramedullary tumor composed of leukemic myeloid cells. It is a rare tumor that can occur in various locations. The association of chloroma with leukemic disease or myeloproliferative disorders is limited to isolated case reports.
Case Description:
We report a case of intracranial chloroma in an elderly man with myelofibrosis and progressive hypereosinophilia. The presence of leukemic cells within his pleural aspirate suggested an incipient acute leukemic state.
Conclusion:
We report the first case of intracranial chloroma associated with hypereosinophilia developing in the course of myelofibrosis. The significance of hypereosinophilia in predicting the likelihood of development of central nervous system chloroma and acute leukemia in a patient with myelofibrosis needs further evaluation.