Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Translation initiation and viral tricks.

Robert J Schneider¹, Ian Mohr

¹Department of Microbiology, NYU School of Medicine, New York, NY 10016, USA. schner01@popmail.med.nyu.edu

Trends in Biochemical Sciences

|March 14, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Purinergic signaling promotes gliomagenesis through nuclear calcium transients.

bioRxiv : the preprint server for biology·2026

Same author

Herpes simplex virus 1 fluidizes the nucleus, enabling condensate formation.

Molecular cell·2026

Same author

AUF1 therapy blocks atrophy, promotes regeneration, re-innervation, and strength for severe muscle injury.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

Herpes simplex virus-1 fluidizes the nucleus enabling condensate formation.

bioRxiv : the preprint server for biology·2025

Same author

De novo assembly of RNA m<sup>6</sup>A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation.

Cell reports·2025

Same author

Multifunctional role of the tumor-associated monocytes/macrophages in the metastatic potential of inflammatory breast cancer.

QJM : monthly journal of the Association of Physicians·2024

Same journal

Intrinsically disordered regions in eukaryotic mRNA decay pathways.

Trends in biochemical sciences·2026

Same journal

A unified mechanism of phosphate export across eukaryotes through EXS domain-containing proteins.

Trends in biochemical sciences·2026

Same journal

Drugging the proteome via large-scale chemoproteomics.

Trends in biochemical sciences·2026

Same journal

Peptideins: Navigating the gray zone of the proteome.

Trends in biochemical sciences·2026

Same journal

A metabolon channels nicotine biosynthesis.

Trends in biochemical sciences·2026

Same journal

Better call chaperone.

Trends in biochemical sciences·2026

See all related articles

Viruses hijack host cell machinery for protein synthesis, using unique mRNA translation methods to outcompete cellular functions. This ensures viral replication, often shutting down host protein production.

Area of Science:

Molecular Biology
Virology
Biochemistry

Background:

Viruses employ diverse strategies to control host cell protein synthesis.
Many viruses manipulate the initiation phase of cellular protein synthesis.
Viral mRNA translation often involves unconventional mechanisms adapted from cellular systems.

Purpose of the Study:

To investigate viral strategies for host cell protein synthesis dominance.
To understand how viruses optimize viral mRNA translation.
To explore viral evasion of host antiviral responses at the translational level.

Main Methods:

Analysis of viral genomic and proteomic data.
In vitro assays to study translation initiation.
Comparative studies of viral and cellular translation machinery.

Related Experiment Videos

Main Results:

Viruses effectively dominate host cell protein synthesis machinery.
Specialized and unconventional mRNA translation strategies are employed by viruses.
Viral translation is prioritized, frequently inhibiting host protein synthesis.

Conclusions:

Viral strategies focus on efficient viral protein production, often at the expense of the host.
Understanding these translational mechanisms is key to antiviral development.
Viruses exhibit remarkable adaptability in hijacking cellular translation systems.