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Polyprotein processing protease of African swine fever virus: purification and biochemical characterization
Daniel Rubio1, Alí Alejo, Irene Rodríguez
1Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Universidad Autónoma de Madrid, Cantoblanco, Spain.
Journal of Virology
|March 14, 2003
Abstract:
The purified recombinant African swine fever virus polyprotein processing protease cleaves the two GG-X sites in polyprotein pp62 with the same efficiency. Cleavage at the site that is first recognized in vivo is not a requisite for cleavage at the second site, suggesting the existence of mechanisms that control the ordered processing of the polyprotein during infection.