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Updated: Aug 8, 2026

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear
Published on: August 24, 2012
Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or
Ming Teng Koh1, Ilene L Bernstein
1Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA.
Abstract:
The involvement of the cAMP-dependent protein kinase A (PKA) signaling pathway in protein synthesis-dependent memory consolidation has been supported by studies of fear conditioning and conditioned taste aversion (CTA). The present experiment examined whether inhibition of PKA activity at the time of memory retrieval impedes or promotes subsequent extinction. When Rp-cAMPS was infused into the amygdala at the time of CTA testing (retrieval), extinction was accelerated. Results confirm recent findings that stored memories become more labile when they are retrieved and extend these findings to CTA memories.
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