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Related Experiment Videos

The cortical substrate of visual extinction.

Hans-Otto Karnath1, Marc Himmelbach, Wilhelm Küker

  • 1Department of Cognitive Neurology, University of Tübingen, Hoppe-Seyler-Str 3, D-72076 Tübingen, Germany. karnath@uni-tuebingen.de

Neuroreport
|March 14, 2003
PubMed
Summary

Lesions in the right hemisphere stroke typically cause visual extinction, not spatial neglect. The temporo-parietal junction (TPJ) is identified as the neural substrate for visual extinction.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Neuroimaging studies reveal two distinct attention networks: voluntary and stimulus-driven.
  • Lesions in the stimulus-driven network were previously thought to cause spatial neglect.

Purpose of the Study:

  • To investigate the neural substrates of spatial neglect and visual extinction.
  • To differentiate the lesion sites responsible for spatial neglect versus visual extinction.

Main Methods:

  • Analysis of consecutively admitted right hemisphere stroke patients.
  • Comparison of lesion sites in patients with visual extinction to neuroimaging activation clusters in healthy subjects.

Main Results:

  • Dissociable cortical substrates were identified for spatial neglect and visual extinction.

Related Experiment Videos

  • Lesions typical for visual extinction were found to overlap with activation clusters in the temporo-parietal junction (TPJ).

    • Conclusions:

    • The temporo-parietal junction (TPJ) is the neural substrate for visual extinction.
    • The findings challenge previous assumptions about lesion effects in the stimulus-driven attention network.