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Published on: January 28, 2019

Intussusception-associated hospitalization among Venezuelan infants during 1998 through 2001: anticipating rotavirus

Irene Pérez-Schael1, Marisol Escalona, Belén Salinas

  • 1Instituto de Biomedicina-Fuvesin, Universidad Central de Venezuela, Ministerio de Salud y Desarrollo Social, Carcas, Venezuela. iperez@telcel.net.ve

The Pediatric Infectious Disease Journal
|March 14, 2003
PubMed

Insights

Intussusception hospitalization rates in Venezuela were 35 per 100,000 infants annually. This study provides crucial data on intussusception epidemiology for rotavirus vaccine trials in developing nations.

Area of Science:

  • Pediatric Gastroenterology
  • Vaccinology
  • Epidemiology

Background:

  • Rotavirus vaccine withdrawal in the US due to intussusception risk.
  • Need for baseline intussusception data in countries for new vaccine trials.
  • Intussusception is a serious concern for pediatric populations.

Purpose of the Study:

  • Assess intussusception hospitalization rates in Carabobo, Venezuela.
  • Describe the epidemiologic and clinical characteristics of intussusception.
  • Provide data for rotavirus vaccine safety monitoring.

Main Methods:

  • Retrospective review of hospital data and clinical records.
  • Inclusion of pediatric patients admitted to eight hospitals in Carabobo.
  • Data collected from January 1, 1998, to December 31, 2001.

Main Results:

  • Average annual hospitalization rate of 35 per 100,000 infants (<1 year).
  • Higher incidence in males (58/100,000) vs. females (29/100,000).
  • 88% of cases required surgical reduction; minimal bowel resection needed.

Conclusions:

  • Provides essential intussusception incidence and epidemiology data for Venezuela.
  • Supports safety assessments for rotavirus vaccine field trials in developing countries.
  • Highlights the need for continued surveillance of intussusception.
Abstract

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