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Epstein-Barr virus and microsatellite instability in gastric carcinogenesis
Mee Soo Chang1, Hye Seung Lee, Hee Sung Kim
1Department of Pathology, Department of Preventive Medicine, and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
The Journal of Pathology
|March 14, 2003
Abstract:
Little information is available concerning the relationship between transforming viruses and microsatellite instability (MSI). We evaluated Epstein-Barr virus (EBV) using in situ hybridization for EBV-encoded small RNAs and MSI using the polymerase chain reaction in surgically resected gastric cancer. The study subjects included 298 consecutive cases of solitary gastric carcinoma, 63 gastric carcinomas in young patients (