The lymph node in experimental xanthomatosis

There is significant, progressive replacement of the lymphoid elements of the lymph node by foam cells in experimental xanthomatosis. These cells first form islands in the subcortical area. Subsequently they involve the medullary cords and finally, they replace the cortex. The xanthomata are higly vascular, consisting of a dense capillary network of samall and short capillaries. These newly visualized capillaries are fully integrated and incorporated in the normal blood supply of the lymph node. No significant distortion of the larger venules and arterioles were observed. It is noteworthy to observe the great capacity of the vascular supply of the lymph node in reacting to situations of significant enlargment and replacement of the lymphoid elements.