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Published on: February 17, 2023
Melatonin in children and adolescents with insomnia: a retrospective study
Anna Ivanenko1, Valerie McLaughlin Crabtree, Riva Tauman
1Kosair Children's Hospital Research Institute, Division of Pediatric Sleep Medicine, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
Insights
Melatonin effectively treated chronic sleep problems in children. Most children showed significant improvement in sleep initiation and maintenance, indicating it is a safe and well-tolerated option.
Area of Science:
- Pediatric Sleep Medicine
- Pharmacology
Background:
- Chronic sleep initiation and maintenance problems are common in children.
- Effective and safe treatment options are needed for pediatric insomnia.
Purpose of the Study:
- To assess the effectiveness and tolerability of melatonin in children with chronic sleep problems.
Main Methods:
- A naturalistic study involving 32 children with chronic sleep issues.
- Melatonin treatment administered 1 hour before bedtime for an average of 2.1 months.
- Dosage averaged 2.0 mg, with outcomes measured by parental reports on sleep latency and awakenings.
Main Results:
- 90.6% of children experienced partial to complete resolution of sleep problems.
- Improvements were noted in sleep latency time and reduced number of awakenings.
- Melatonin was reported as safe and well-tolerated by participants.
Conclusions:
- Melatonin appears to be an effective and well-tolerated treatment for chronic insomnia in children.
- Further research can explore optimal dosing and long-term effects.
- Pediatric sleep medicine centers can consider melatonin as a therapeutic option.
Abstract:
Effectiveness and tolerability of melatonin was assessed in 32 children (mean age 9.6 +/- 4.5 years) with chronic sleep initiation and sleep maintenance problems treated naturalistically in a pediatric sleep medicine center. Children received melatonin for an average of 2.1 +/- 2.0 months at a final average dose of 2.0 +/- 1.2 mg administered 1 hour before bedtime. Twenty-nine (90.6%) children exhibited partial improvement to complete resolution of their sleep problems as measured by sleep latency time and number of awakenings reported by parents. Thus, melatonin may be effective, safe, and well tolerated in the treatment of chronic insomnia in children.
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