Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma lipid composition and LDL oxidation.

Patrizia Brizzi1, Giancarlo Tonolo, Francesca Carusillo

  • 1Diabetes Service, Department of Medicine, University of Sassari, Italy. patbri@katamail.com

Clinical Chemistry and Laboratory Medicine
|March 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of metformin on metabolomic and circulating miRNAs profile in type 2 diabetes mellitus patients: a pilot analysis of sex differences.

European journal of pharmacology·2025
Same author

Do Sex and Gender Interact with the Biological Actions of Taurine? A Critical Rereading of the Literature.

International journal of molecular sciences·2025
Same author

In vitro phenotypic characterisation of two genotype I African swine fever viruses with genomic deletion isolated from Sardinian wild boars.

Veterinary research·2024
Same author

The Long-Jumping of African Swine Fever: First Genotype II Notified in Sardinia, Italy.

Viruses·2024
Same author

Carnitine derivatives beyond fatigue: an update.

Current opinion in gastroenterology·2023
Same author

Smoking and combined oral contraceptives should be considered as an independent variable in sex and gender-oriented studies.

Toxicology and applied pharmacology·2022

The LDL/Triglycerides (TG) and LDL/HDL ratios are key predictors of in vivo low-density lipoprotein (LDL) oxidation. These ratios are crucial for assessing LDL oxidation, even with normal cholesterol levels, highlighting the importance of lipid homeostasis.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Oxidative Stress Research

Background:

  • Low-density lipoprotein (LDL) oxidation is influenced by lipid composition and plasma antioxidant capacity.
  • Understanding predictors of LDL oxidation is vital for cardiovascular health assessment.

Purpose of the Study:

  • To investigate the relationship between plasma lipid composition and LDL oxidation in vivo.
  • To determine if LDL-cholesterol/triglycerides (LDL-C/TG) and LDL-cholesterol/HDL-cholesterol (LDL-C/HDL-C) ratios predict LDL oxidation.

Main Methods:

  • Studied 87 volunteers across a range of ages, analyzing plasma lipids and LDL oxidation.
  • Measured LDL oxidation via conjugated diene levels (BDC) in isolated LDL.
  • Expressed results as BDC/L (oxidized LDL level) and BDC/LDL-C (LDL oxidation degree).

Related Experiment Videos

Main Results:

  • BDC/L correlated with age, total cholesterol, LDL-C, apolipoprotein B, and TG.
  • BDC/LDL-C negatively correlated with total cholesterol, apolipoprotein B, LDL/TG, and LDL/HDL ratios.
  • LDL/TG and LDL/HDL ratios emerged as significant predictors of in vivo LDL oxidation.

Conclusions:

  • The LDL/TG ratio is a primary determinant of LDL oxidation, emphasizing triglyceride importance.
  • The LDL/HDL ratio is also critical, suggesting a protective role for HDL against LDL oxidation.
  • Plasma lipid parameters should be assessed by their ratios to reflect lipid homeostasis and predict LDL oxidation.