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Parathyroid gland carcinoma in a Wistar rat
V Pace1, S Scarsella, E Perentes
1Dompè SpA, R & D, L'Aquila, Italy. virgilio.pace@dompe.it.
Veterinary Pathology
|March 15, 2003
Summary
A rare anaplastic carcinoma was identified in a Wistar rat's parathyroid gland. This finding highlights potential thyroid and parathyroid tumor development in carcinogenicity studies.
Area of Science:
- Veterinary Pathology
- Oncology
- Toxicology
Background:
- Carcinogenicity studies are crucial for evaluating the safety of substances.
- Rats are commonly used models in toxicological research.
- Parathyroid gland tumors are uncommon in rodent models.
Observation:
- A 2-year-old male Wistar rat developed an anaplastic carcinoma in one parathyroid gland.
- The tumor exhibited pleomorphic and dense cells with atypical mitoses, alongside monomorphic cells forming cystic spaces.
- Local invasion and compression of the thyroid gland were noted.
Findings:
- Immunohistochemistry revealed positivity for parathyroid hormone and negativity for thyroid transcription factor.
- Proliferative activity was assessed using Ki-67 and proliferating cell nuclear antigen.
- Microscopic and immunohistochemical data supported the diagnosis of parathyroid carcinoma.
Implications:
- This case contributes to understanding parathyroid gland neoplasia in Wistar rats.
- Findings may inform risk assessment in toxicological studies involving similar compounds.
- Highlights the importance of thorough histopathological examination in rodent carcinogenicity bioassays.