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Related Experiment Videos

Genetic predisposition to external apical root resorption.

Riyad A Al-Qawasmi1, James K Hartsfield, Eric T Everett

  • 1School of Dentistry, Indiana University, Indianapolis 46202-5186, USA.

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
|March 15, 2003
PubMed
Summary

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Genetic factors significantly influence external apical root resorption (EARR), a side effect of orthodontic treatment. The IL-1B gene polymorphism is linked to increased EARR risk, particularly in maxillary incisors.

Area of Science:

  • Genetics
  • Orthodontics
  • Oral Biology

Background:

  • External apical root resorption (EARR) is a common, often undesirable, outcome of orthodontic therapy.
  • Previous research suggests a significant genetic predisposition to EARR.
  • Identifying genetic markers can help predict and potentially mitigate EARR risk.

Purpose of the Study:

  • To investigate the association between interleukin IL-1 gene polymorphisms (IL-1A and IL-1B) and EARR.
  • To determine the genetic contribution of IL-1B to EARR in a family-based cohort.

Main Methods:

  • Analysis of IL-1A and IL-1B gene polymorphisms using DNA from buccal swabs of 35 white American families.
  • Application of linkage and association methods to assess EARR in various tooth types (maxillary incisors, mandibular incisors, mandibular first molars).

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Main Results:

  • A highly significant linkage disequilibrium was found between IL-1B polymorphism and EARR (P =.0003).
  • The IL-1B polymorphism explains 15% of the variation in maxillary incisor EARR.
  • Homozygosity for IL-1B allele 1 confers a 5.6-fold increased risk for EARR exceeding 2 mm.

Conclusions:

  • The IL-1B gene polymorphism is a significant genetic risk factor for developing external apical root resorption.
  • This finding supports the view of EARR as a complex trait influenced by multiple genetic and environmental factors.
  • Understanding genetic predispositions like IL-1B variations is crucial for managing orthodontic treatment outcomes.