[Genetic factors of osteoporosis and polymorphisms]

Osteoporosis is a common disease with a strong genetic factors. Twin studies have shown that genetic factors play an important role in regulating bone turnover and bone mineral density. These phenotypes are determined by the combined effects of several genes and environmental influences. A great deal of research has been done on candidate genes, among the best studied are vitamin D receptor gene. From a clinical standpoint, advances in knowledge about the prospect of developing genetic markers for the assessment of fracture risk will be used as targets for the design of new drugs for the prevention and treatment of osteoporosis.