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Updated: May 24, 2026
16:15
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
[Causes of late renal transplant dysfunction]
Attila Szabó1, Veronika Müller
1Semmelweis Egyetem, Altalános Orvostudományi Kar, I. Sz. Gyermekklinika, Budapest. szabat@gyer1.sote.hu
Orvosi Hetilap
|March 18, 2003
Summary
Renal allograft loss is now mainly due to chronic allograft nephropathy, influenced by both immune and non-immune factors. Understanding these risks improves long-term kidney transplant outcomes.
Area of Science:
- Nephrology and Immunology
- Transplantation Science
Context:
- Renal transplantation is the primary treatment for end-stage renal failure.
- Graft loss causes have shifted from acute rejection to chronic allograft nephropathy.
- Chronic allograft nephropathy is multifactorial, involving alloantigen-dependent and -independent factors.
Purpose:
- To review current knowledge on risk factors affecting long-term renal allograft function.
- To delineate the evolving landscape of renal allograft loss causes.
- To synthesize information on the pathophysiology of chronic allograft nephropathy.
Summary:
- Chronic allograft nephropathy, the leading cause of renal allograft loss, results from diverse factors including alloantigen-dependent (rejection, histoincompatibility) and alloantigen-independent elements (ischemia, donor characteristics, post-transplant complications).
- Endothelial injury is a common pathway, triggering inflammatory responses and graft remodeling.
- Immunosuppressants and non-compliance also significantly impact graft survival.
Impact:
- Provides a comprehensive overview of factors contributing to long-term renal allograft dysfunction.
- Highlights the shift in graft loss etiology, emphasizing chronic processes.
- Informs strategies for mitigating risks and improving patient outcomes in renal transplantation.
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