[Functions of peritoneal macrophages during adaptation to dosed heat factor]

Experiments on mice were made to study functional activity of peritoneal macrophages in adaptation of the animals to dosed heat factor by a phagocytic ability of the cells, chemiluminescence (CL), activity of acid phosphatase and phagocyte production of lymphocyte-activating factors (LAF). Daily overheating of mice (20 min, 43-44 degrees C) for 5, 10, 20 and 30 days resulted in suppression of macrophage function. The deepest depression of phagocyte functional activity was observed on overheating day 10-20. This was evident from subnormal phagocytic ability of the cells, suppression of CL response and activity of acid macrophage phosphatase, low production of LAF. Thermotraining led to recovery of macrophage function as the studied parameters returned to control 40 days after overheating onset.