[Ammonia-neutralizing function of hepatocytes after experimental liver resection]

The experimental study has established that a 15-20% resection of a hepatic mass in healthy rats inhibits glutamine formation in hepatocytes and stimulates its decomposition in liver cells promoting ammonia accumulation in the operated liver. The hepatocyte urea synthetizing cycle can not prevent accumulation of ammonia in the liver and raise their urea content even if arginase activity is high. Inhibition of GDG activity in the operated liver not only limits formation of ammonia during glutamate deamination but also results in glutamine deamination inhibition in hepatocytes. These disorders of hepatocytic ammonia neutralizing function persist for 21 days after hepatic resection.