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Related Experiment Videos

Ticlopidine-induced cholestatic hepatitis.

Yair D Skurnik1, Alexandra Tcherniak, Karl Edlan

  • 1Day Care Clinic, Department of Internal Medicine B, Kaplan Medical Center, Rehovot, Israel.

The Annals of Pharmacotherapy
|March 18, 2003
PubMed
Summary

Ticlopidine can cause rare, prolonged cholestatic hepatitis, potentially immune-mediated. Monitoring liver function is advised, though this complication is decreasing with newer antiplatelet drugs.

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Area of Science:

  • Hepatology
  • Pharmacology
  • Immunology

Background:

  • Ticlopidine is an antiplatelet agent used after percutaneous coronary angioplasty.
  • Cholestatic hepatitis is a rare but serious adverse drug reaction.
  • Few cases of ticlopidine-induced cholestatic hepatitis are reported in English literature.

Observation:

  • Two patients developed prolonged cholestatic hepatitis after ticlopidine treatment.
  • Hepatitis onset occurred after percutaneous coronary angioplasty.
  • Symptoms resolved completely after drug discontinuation.

Findings:

  • Ticlopidine induced cholestatic hepatitis in the reported cases.
  • In vitro studies showed T-cell stimulation by ticlopidine in patients, suggesting an immune mechanism.

Related Experiment Videos

  • Hepatitis can manifest weeks after drug cessation and have a prolonged course.

    • Implications:

    • Cholestatic hepatitis is a rare, possibly immune-mediated, adverse effect of ticlopidine.
    • Monitoring liver function tests is recommended for patients on ticlopidine.
    • The incidence of this complication is expected to decline with the use of clopidogrel.