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Related Experiment Videos

Recurrent cholestasis due to ampicillin.

Seyfettin Köklü1, Osman Yüksel, Levent Filik

  • 1Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. gskoklu@yahoo.com

The Annals of Pharmacotherapy
|March 18, 2003
PubMed
Summary

Ampicillin can cause recurrent cholestatic hepatitis, a rare adverse drug reaction. This case highlights the importance of considering ampicillin in liver injury diagnosis.

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Area of Science:

  • Hepatology
  • Pharmacology
  • Gastroenterology

Background:

  • Ampicillin is a widely used antibiotic.
  • Hepatotoxicity from ampicillin is uncommon, typically presenting as hepatocellular injury.
  • Cholestatic-type liver injury from ampicillin is exceptionally rare.

Observation:

  • A 23-year-old male experienced recurrent, self-limiting cholestatic symptoms.
  • Each episode of cholestasis was preceded by ampicillin use.
  • Symptoms resolved upon drug discontinuation, with no recurrence after one year off ampicillin.

Findings:

  • A probable causal link was established between ampicillin and recurrent cholestatic hepatitis.
  • This case represents a rare instance of ampicillin-induced cholestatic liver injury.

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Implications:

  • Clinicians should consider ampicillin as a potential cause of recurrent cholestatic hepatitis.
  • Awareness of this rare adverse effect is crucial for accurate diagnosis and patient management.