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Pyridazinones as selective cyclooxygenase-2 inhibitors
Chun Sing Li1, Christine Brideau, Chi Chung Chan
1Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8. chunsing_li@merck.com
Bioorganic & Medicinal Chemistry Letters
|March 18, 2003
Abstract:
Pyridazinone was found to be an excellent core template for selective COX-2 inhibitors. Two potent, selective and orally active COX-2 inhibitors, which were highly efficacious in rat paw edema and rat pyresis models, have been obtained.