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Versatile inducible activation system of Akt/PKB signaling pathway in mice
Jens Kroll1, Patricia Cobo, Thomas N Sato
1The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8573, USA.
Genesis (New York, N.Y. : 2000)
|March 18, 2003
Abstract:
We report a transgenic mouse line in which Akt/protein kinase B (PKB) pathway can be activated in an inducible manner in defined cell types. In this transgenic mouse line, Cre expression allows the expression of a tamoxifen-activatable form of Akt/PKB in a defined cell type. Subsequent injection of tamoxifen triggers the transient activation of Akt/PKB in mice. Thus, this transgenic line allows the transient activation of Akt/PKB pathway in a predefined cell type. We expect that this transgenic system will provide a unique tool to study the roles of Akt/PKB pathway in mice.