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TAP1 gene AccI polymorphism is associated with atopic bronchial asthma
Liang-Wen Hang1, Te-Chun Hsia, Wen-Chi Chen
1Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan.
Journal of Clinical Laboratory Analysis
|March 18, 2003
Summary
Genetic variations in the transporter associated with antigen processing 1 (TAP1) gene were investigated for asthma susceptibility. The TAP1 AccI polymorphism showed a significant association, suggesting it may indicate atopic bronchial asthma risk.
Area of Science:
- Immunogenetics
- Respiratory Medicine
- Molecular Biology
Background:
- Asthma is characterized by hyperresponsive airways and inflammation.
- The transporter associated with antigen processing 1 (TAP1) gene plays a role in antigen processing and is implicated in asthma pathogenesis.
Purpose of the Study:
- To investigate whether TAP1 gene polymorphisms serve as a genetic marker for bronchial asthma susceptibility.
- To evaluate the association between atopic bronchial asthma and TAP1 gene polymorphisms.
Main Methods:
- Study included 43 healthy controls and 116 patients with allergic asthma.
- Polymerase chain reaction (PCR)-based restriction analysis was used to detect TAP1 gene polymorphisms.
- Statistical analysis was performed to evaluate associations between asthma and TAP1 polymorphisms.
Main Results:
- No significant difference was found for the TAP1 DpnII polymorphism between control and asthma groups (P=0.752).
- A significant difference was observed for the TAP1 AccI polymorphism between the control and asthma groups (P=0.020).
- The odds ratio (OR) for GG homozygotes of the TAP1 AccI polymorphism was 229.8 compared to AA homozygotes, indicating a strong association.
Conclusions:
- The TAP1 AccI polymorphism may serve as a potential indicator for atopic bronchial asthma.
- Further research is warranted to elucidate the precise role of TAP1 gene variations in asthma development.