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Review article: visceral hypersensitivity.

H Mertz1

  • 1Department of Medicine and Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Howard.Mertz@mcmail.vanderbilt.edu

Alimentary Pharmacology & Therapeutics
|March 19, 2003
PubMed
Summary

Visceral hypersensitivity, a common issue in functional bowel disorders, explains gut pain and discomfort. New treatments targeting neurotransmitters offer hope for managing these sensitive gut conditions.

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Area of Science:

  • Gastroenterology and Neurogastroenterology

Background:

  • Visceral hypersensitivity is a hallmark of functional bowel disorders (FBDs).
  • FBDs often involve referred pain, suggesting widespread sensory changes.
  • Gut sensitivity can be triggered by normal or abnormal gut activity.

Purpose of the Study:

  • To explore the role of visceral hypersensitivity in FBD symptoms.
  • To investigate potential triggers and modulators of visceral hypersensitivity.
  • To highlight emerging therapeutic strategies for FBDs.

Main Methods:

  • Review of existing literature on visceral hypersensitivity and FBDs.
  • Analysis of the relationship between gut motor function and pain perception.
  • Discussion of pharmacological interventions targeting neurotransmitter pathways.

Main Results:

  • Visceral hypersensitivity is prevalent across various FBDs.
  • Somatic referral of visceral pain is common in these conditions.
  • Hypersensitivity may be exacerbated by stress and symptom flares, requiring further research.

Conclusions:

  • Visceral hypersensitivity is a key mechanism underlying FBD symptoms.
  • Pharmacological targeting of neurotransmitters represents a promising therapeutic avenue.
  • This approach heralds a new era in treating functional gastrointestinal disorders.

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