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Target concentration of propofol required to insert the laryngeal mask airway in children

X Viviand1, L Berdugo, C Aubry De La Noé

  • 1Department of Anaesthesia, Hôpital Nord, Marseille Cedex, France. xviviand@aphm.fr

Paediatric Anaesthesia
|March 19, 2003
PubMed

Insights

This study determined propofol target concentration curves for laryngeal mask airway insertion in children. The target-controlled infusion technique proved safe and effective for anesthesia induction.

Area of Science:

  • Anesthesiology
  • Pharmacokinetics
  • Pediatric Anesthesia

Background:

  • Laryngeal mask airway (LMA) insertion requires precise anesthetic dosing.
  • Determining target concentration (CPRED) curves for propofol is crucial for pediatric LMA procedures.

Purpose of the Study:

  • To establish target concentration (CPRED) curves for laryngeal mask airway (LMA) insertion in pediatric patients.
  • To evaluate the safety and efficacy of target-controlled infusion (TCI) for anesthesia induction and LMA placement in children.

Main Methods:

  • Prospective study involving 72 unpremedicated children (3-10 years, ASA I).
  • Propofol CPRED for LMA insertion determined using sequential allocation.
  • Insertion conditions assessed as satisfactory, excellent, or unacceptable.

Main Results:

  • CPRED50 and CPRED90 values varied based on pharmacokinetic models (Kataria, Marsh, Schüttler).
  • Satisfactory LMA insertion CPRED50 was 7.86 µg/mL (Kataria), increasing with pharmacokinetic model adjustments.
  • Excellent insertion conditions required higher propofol concentrations across all models.

Conclusions:

  • Target-controlled infusion (TCI) is a safe and effective method for anesthesia induction.
  • TCI facilitates successful laryngeal mask airway insertion in pediatric patients.
  • Established CPRED curves provide valuable guidance for pediatric anesthesia.
Abstract

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