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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Prostate cancer epidemiology.

Henrik Grönberg1

  • 1Department of Radiation Sciences/Oncology, Umeå University, 901 85, Umeå, Sweden. henrik.gronberg@oc.umu.se

Lancet (London, England)
|March 19, 2003
PubMed
Summary

Prostate cancer diagnoses are rising globally, yet its causes remain unclear. Further research into ethnic variations and familial links is crucial for understanding and preventing this disease.

Area of Science:

  • Oncology
  • Epidemiology
  • Genetics

Background:

  • Prostate cancer incidence is increasing worldwide, necessitating greater understanding for prevention.
  • While diet and genetics offer some clues, prostate cancer causes are less understood than other major cancers.
  • Key knowledge gaps include ethnic variations in incidence and factors driving familial prostate cancer clustering.

Purpose of the Study:

  • To highlight the importance of understanding prostate cancer causes.
  • To identify critical areas for future research, including ethnic disparities and hereditary factors.
  • To emphasize the need for enhanced prevention strategies based on improved etiological insights.

Main Methods:

  • Review of epidemiological studies on prostate cancer risk factors.

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  • Analysis of existing data on ethnic variations in prostate cancer incidence.
  • Examination of research concerning familial clustering of prostate cancer cases.

    • Main Results:

    • Prostate cancer's etiology is complex and not fully elucidated.
    • Significant differences in prostate cancer incidence exist across ethnic populations.
    • Familial aggregation suggests a genetic component in prostate cancer development.

    Conclusions:

    • Further investigation into environmental, genetic, and ethnic factors is essential.
    • Understanding these factors will facilitate targeted prevention and early detection strategies.
    • Addressing knowledge gaps is critical for global prostate cancer control efforts.