Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemoglobinuria with ribavirin treatment.

Omar I Massoud1, Wael I Yousef, Kevin D Mullen

  • 1Department of Medicine, Metrohealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Journal of Clinical Gastroenterology
|March 19, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibrosis improvement in patients with HCV treated with direct-acting antivirals.

European journal of gastroenterology & hepatology·2020
Same author

Nomenclature and definition of hepatic encephalopathy - An update.

Clinical liver disease·2019
Same author

Hepatocellular carcinoma surveillance: An evidence-based approach.

World journal of gastroenterology·2019
Same author

Understanding the impact of neurologic complications in patients with cirrhosis.

SAGE open medicine·2019
Same author

Effect of Hepatitis C Treatment on Renal Function in Liver Transplant Patients.

Journal of clinical and translational hepatology·2019
Same author

Resolution of ascites and hepatic encephalopathy and absence of variceal bleeding in decompensated hepatitis C virus cirrhosis patients.

JGH open : an open access journal of gastroenterology and hepatology·2019

Black urine, a sign of significant hemolysis, can occur in patients receiving combination therapy for chronic hepatitis C. This previously unreported side effect warrants monitoring hemoglobin levels during treatment.

Area of Science:

  • Hepatology
  • Pharmacology
  • Oncology

Background:

  • Chronic hepatitis C virus infection is a leading cause of liver disease, including cirrhosis and hepatocellular carcinoma.
  • Standard treatment involves combination therapy with ribavirin and interferon-alpha, which causes various side effects.
  • Hemolysis is a known side effect of ribavirin, but black urine due to hemoglobinuria has not been previously documented.

Observation:

  • Two patients undergoing combination therapy for chronic hepatitis C presented with black urine.
  • This dark urine was attributed to hemoglobinuria, indicating a severe degree of hemolysis.
  • Anecdotal reports suggest this side effect may be more prevalent than previously recognized.

Findings:

  • Black urine (hemoglobinuria) is a newly identified adverse effect of combination therapy for chronic hepatitis C.

Related Experiment Videos

  • The presence of black urine signifies marked hemolysis.
  • This observation highlights the need for vigilant monitoring of patients undergoing this treatment.

    • Implications:

    • Clinicians should be aware of the potential for black urine as an indicator of significant hemolysis in patients treated for chronic hepatitis C.
    • Prompt measurement of hemoglobin levels is crucial upon observing dark urine in patients on this therapy.
    • Further research may be needed to understand the incidence and mechanisms of this adverse event.