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Role of estrogen receptor-alpha in pharmacogenetics of estrogen action

David M Herrington1

  • 1Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. dherring@wfubmc.edu

Current Opinion in Lipidology
|March 19, 2003
PubMed
Abstract

Insights

Estrogen receptor-alpha gene variants influence how women respond to hormone therapy, potentially affecting cardiovascular health. Further research is needed to confirm their impact on clinical cardiovascular events.

Area of Science:

  • Genetics
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Hormone replacement therapy (HRT) has shifted from presumed cardiovascular benefit to confirmed harm based on recent trials.
  • Understanding discrepancies in HRT's effects on cardiovascular risk markers versus clinical events is crucial.

Purpose of the Study:

  • To review data on estrogen receptor-alpha (ER-alpha) polymorphisms and their role in HRT response.
  • To investigate the influence of genetic factors on individual responses to estrogen therapy.

Main Methods:

  • Review of recent clinical trial data on hormone replacement therapy.
  • Analysis of emerging evidence linking estrogen receptor variants to intermediate cardiovascular endpoints.

Main Results:

  • Estrogen receptor-alpha variants are associated with differential responses to HRT in various estrogenic pathways.
  • New evidence suggests a link between specific estrogen receptor variants and HDL response to HRT.

Conclusions:

  • Common ER-alpha variants affect HRT response but their impact on clinical cardiovascular events remains unknown.
  • Research on ER-alpha, ER-beta, and progesterone receptor variants may refine HRT decision-making.

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