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Drug-induced renal function impairment: a population-based survey
Taco B M Monster1, Paul E de Jong, Lolkje T W de Jong-van den Berg
1Department of Social Pharmacy, Pharmacoepidemiology and Pharmacotherapy, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands.
Pharmacoepidemiology and Drug Safety
|March 20, 2003
Summary
This study reveals common drug groups linked to altered kidney function in the general population. Unexpected associations with certain medications warrant further investigation into drug safety and renal health.
Area of Science:
- Nephrology
- Pharmacology
- Epidemiology
Background:
- Drug effects on renal function are primarily known from limited studies.
- Previous research focused on specific patient groups, not the general population.
Purpose of the Study:
- To identify drug groups associated with altered kidney function in the general population.
- To expand understanding beyond experimental and case-report data.
Main Methods:
- Utilized baseline data from a population-based cohort of 8592 subjects.
- Defined hyperfiltration and hypofiltration based on age- and sex-corrected creatinine clearance.
- Assessed drug use within the year prior to kidney function measurement.
Main Results:
- Hyperfiltration was more prevalent with anti-diabetics, corticosteroids, and sex hormones.
- Hypofiltration was more common in users of beta blockers, ACE inhibitors, statins, NSAIDs, and others.
- Certain drug classes showed reduced hyperfiltration, including anti-thrombotics and diuretics.
Conclusions:
- Identified expected drug associations (e.g., cardiovascular drugs) and some unexpected ones.
- Highlights the need for further research into specific drug classes and their renal impact.
- Emphasizes the importance of considering medication effects on kidney function in the general population.