Combination oral agent and insulin therapy for type 2 diabetes mellitus
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1MedStar Clinical Research Center, 650 Pennsylvania Avenue, SE, Suite 50, Washington, DC 20003, USA. maureen.passaro@medstar.net
Abstract:
Type 2 diabetes is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. Over time, there is progressive beta-cell failure. Combination oral and insulin therapy aims at treating both the defects in underlying pathophysiology and replacing insulin once beta-cell failure has occurred. Combination therapy is routinely used in the management of diabetes to reduce hemoglobin A1c, weight gain, and the number of insulin injections a patient requires. This article examines the effects of combining various oral agents with insulin on glycemic control, hypoglycemia, weight gain, and nonglycemic benefits of these combinations.
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