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Systemic-to-pulmonary artery shunt thrombosis in a neonate with factor V Leiden mutation
Janet M Simsic1, Walter E Uber, John Lazarchick
1Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. simsicjm@musc.edu
The Annals of Thoracic Surgery
|March 20, 2003
Abstract:
We present the case of a newborn male with D-transposition of the great arteries, ventricular septal defect, and subpulmonary stenosis who experienced two episodes of systemic-to-pulmonary artery shunt thrombosis. Hematologic evaluation revealed heterozygous factor V Leiden mutation. This report emphasizes the importance of evaluation for inherited coagulation disorders in pediatric patients with unexpected thrombotic complications.