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Identification of a novel series of selective 5-HT7 receptor antagonists
Ian T Forbes1, David G Cooper, Emma K Dodds
1GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.
Bioorganic & Medicinal Chemistry Letters
|March 20, 2003
Abstract:
Novel 5-HT(7) receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Molecular modelling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by compound (25), SB-691673.