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Structure-activity relationships studies of the anti-angiogenic activities of linomide
Jiandong Shi1, Zili Xiao, Michael A Ihnat
1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Bioorganic & Medicinal Chemistry Letters
|March 20, 2003
Abstract:
The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.