Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial memory performance of freely-moving squirrel monkeys.

Nandor Ludvig1, Hai M Tang, Howard Eichenbaum

  • 1Department of Physiology & Pharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Box 31, Brooklyn 11203, USA. ludvin10@bmec.hscbklyn.edu

Behavioural Brain Research
|March 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body mass loss is a surrogate marker of frailty in heart failure.

International journal of cardiology·2018
Same author

The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales.

Current biology : CB·2018
Same author

Memory creation and modification: Enhancing the treatment of psychological disorders.

The American psychologist·2018
Same author

Publisher Correction: Viewpoints: how the hippocampus contributes to memory, navigation and cognition.

Nature neuroscience·2017
Same author

Viewpoints: how the hippocampus contributes to memory, navigation and cognition.

Nature neuroscience·2017
Same author

Temporal binding function of dorsal CA1 is critical for declarative memory formation.

Proceedings of the National Academy of Sciences of the United States of America·2017

Squirrel monkeys develop short-term and long-term spatial memory in a novel 3D task. This paradigm assesses cognitive map formation and can be used for neurobiological studies and drug screening in primates.

Area of Science:

  • Neuroscience
  • Primate Cognition
  • Spatial Memory

Background:

  • Cognitive map formation in non-human primates is under-explored.
  • A new paradigm is needed to assess spatial memory in 3D environments.

Purpose of the Study:

  • To develop and validate a novel paradigm for assessing spatial memory and cognitive map formation in squirrel monkeys.
  • To investigate the development of short-term and long-term spatial memory in these animals.

Main Methods:

  • Squirrel monkeys (Saimiri sciureus) navigated a 3D test chamber with baited and non-baited food ports.
  • Animals learned to locate hidden food rewards, with performance measured by correct choices (CC) and incorrect choices (IC).
  • Spatial Memory Performance Index (SMPI) was calculated as (CC-IC)/CC over multiple sessions.

Related Experiment Videos

Main Results:

  • SMPI was significantly above zero in the first session, indicating short-term spatial memory.
  • By the second day (session 5), SMPI significantly increased, demonstrating long-term spatial memory development.
  • This improvement correlated with a decrease in incorrect choices (reaching non-baited ports).

Conclusions:

  • The developed paradigm effectively assesses spatial memory and cognitive map formation in squirrel monkeys.
  • This model is suitable for studying the neurobiological underpinnings of spatial memory.
  • The paradigm can be utilized for screening cognition-enhancing drugs in a primate model.