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Updated: Aug 8, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
Does knowledge about the genetics of breast cancer differ between nongeneticist physicians who do or do not discuss
Teresa Doksum1, Barbara A Bernhardt, Neil A Holtzman
1Abt Associates Inc., Cambridge, Massachusetts 02138, USA.
Purpose:
To assess nongeneticist physicians' knowledge and experience with BRCA1/2 testing.
Methods:
In 1998, 2250 internists, obstetrician-gynecologists (Ob-Gyns), and oncologists practicing in Pennsylvania, Maryland, Massachusetts, New York, or New Jersey were surveyed.
Results:
Forty percent responded. Only 13% of internists, 21% of Ob-Gyns, and 40% of oncologists correctly answered all four knowledge questions about genetic aspects of breast cancer and testing for it. Knowledge was associated with discussing or ordering only among oncologists.
Conclusion:
Despite deficiencies in their knowledge about the genetic aspects of breast cancer, many nongeneticist physicians have discussed testing and some have ordered testing.
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