[CD4+, CD25+ regulatory T-lymphocytes: current concepts and therapeutic potential]

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Benoît Salomon1

  • 1Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires. CNRS UMR 7087, CERVI, Hôpital de la Pitié-Salpêtrière, Bd de l'hôpital, 75651, Paris.

Journal De La Societe De Biologie
|March 21, 2003
PubMed

The subpopulation of CD4 T cells, characterized by a constitutive expression of CD25, plays a critical role in the regulation of multiple auto-immune diseases. These CD4+CD25+ T cells may act by inhibiting the activation of both CD4+ and CD8+ conventional T cells. These cells have a thymic origin and are auto-reactive. They have therapeutic potentials, not only in the control of autoimmune diseases, but also in the control of allograft rejection and graft-versus-host disease.

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