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Spasticity in multiple sclerosis.

M P Barnes1, R M Kent, J K Semlyen

  • 1Academic Unit of Neurological Rehabilitation, Hunters Moor Regional Neurological Rehabilitation Centre, Newcastle upon Tyne NE2 4NR, UK. m.p.barnes@btinternet.com

Neurorehabilitation and Neural Repair
|March 21, 2003
PubMed
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Spasticity affects nearly half of people with multiple sclerosis (MS), significantly increasing disability. Current treatments are often inadequate, highlighting a need for better management strategies for MS spasticity.

Area of Science:

  • Neurology
  • Clinical Research
  • Rehabilitation Medicine

Background:

  • Spasticity is a common and often debilitating symptom in multiple sclerosis (MS).
  • Understanding its prevalence and impact on functional independence is crucial for effective patient care.
  • Current pharmacological interventions for MS spasticity may not be optimal.

Purpose of the Study:

  • To determine the prevalence of clinically significant spasticity in a random sample of individuals with MS in Newcastle upon Tyne.
  • To evaluate the adequacy of current pharmacological treatments for spasticity in this population.
  • To assess the relationship between spasticity and overall disability levels in people with MS.

Main Methods:

  • A comparative study design involving 68 adults with clinically definite MS.

Related Experiment Videos

  • Assessment of functional independence using the Newcastle Independence Assessment Form (NIAF), Functional Independence Measure (FIM), and Kurtzke Extended Disability Status Scale (EDSS).
  • Spasticity was quantified using the Modified Ashworth Scale, and medication appropriateness was reviewed by a rehabilitation physician.

    • Main Results:

    • 47% of participants exhibited clinically significant spasticity (Modified Ashworth Score ≥ 2).
    • 78% were on oral antispastic medication, yet 50% required treatment adjustments.
    • Individuals with spasticity demonstrated significantly higher disability levels compared to those without.

    Conclusions:

    • Spasticity is highly prevalent in the MS population and strongly associated with reduced functional independence.
    • Pharmacological treatment for spasticity in MS patients is frequently suboptimal.
    • There is a clear need for enhanced education and information for both healthcare professionals and individuals with MS regarding spasticity management.