Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular cytogenetic parameters in Ewing sarcoma.

A Amiel1, A Ohali, M Fejgin

  • 1Genetic Institute, Sapir Medical Center, Kfar-Saba, Israel. amielaliza@clalit.org.il

Cancer Genetics and Cytogenetics
|March 21, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IMAP's Role in Understanding Particle Injection and Energization Throughout the Heliosphere.

Space science reviews·2026
Same author

Advanced Methods for Analyzing in-Situ Observations of Magnetic Reconnection.

Space science reviews·2024
Same author

Charge-State-Dependent Energization of Suprathermal Ions During Substorm Injections Observed by MMS in the Magnetotail.

Journal of geophysical research. Space physics·2020
Same author

The Space Physics Environment Data Analysis System (SPEDAS).

Space science reviews·2019
Same author

Autogenous and efficient acceleration of energetic ions upstream of Earth's bow shock.

Nature·2018
Same author

Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.

Bone marrow transplantation·2017

Random aneuploidy, a genomic instability marker, significantly predicts tumor relapse in Ewing sarcoma (EWS). This finding aids in identifying high-risk patients for Ewing sarcoma, guiding treatment strategies.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Ewing sarcoma (EWS) is a rare bone and soft tissue cancer.
  • Understanding genomic instability in EWS is crucial for predicting patient outcomes.

Purpose of the Study:

  • To investigate genomic instability and random aneuploidy in Ewing sarcoma.
  • To correlate these findings with tumor relapse and telomerase activity.

Main Methods:

  • Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) were employed.
  • Telomerase activity was assessed in 16 EWS cases and 7 controls.

Main Results:

  • Secondary chromosomal aberrations, including gains of chromosomes 8 and 12, were identified.

Related Experiment Videos

  • A significant correlation was found between random aneuploidy and tumor relapse (P = 0.0047).
  • Higher telomerase activity and other abnormal parameters were observed in relapsed cases but lacked statistical significance.

    • Conclusions:

    • Random aneuploidy is a sensitive predictor of tumor relapse in Ewing sarcoma.
    • Genomic instability markers may offer prognostic value in EWS management.