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Receptor sensitivity: when T cells lose their sense of self
Kristin A Hogquist1, Timothy K Starr, Stephen C Jameson
1University of Minnesota, Center for Immunology, 312 Church Street, S.E., Minneapolis, Minnesota 55455, USA. hogqu001@umn.edu
Current Biology : CB
|March 21, 2003
Abstract:
The T-cell antigen receptor binds to self-MHC molecules with low affinity. Recent reports disagree as to whether this interaction sensitizes or desensitizes the receptor. Here we discuss how these findings might be reconciled.