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Related Experiment Videos

IL-4 exacerbates anaphylaxis.

Richard T Strait1, Suzanne C Morris, Kristi Smiley

  • 1Division of Emergency Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|March 21, 2003
PubMed
Summary
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Interleukin-4 (IL-4) significantly worsens anaphylaxis by increasing vascular permeability. This cytokine

Area of Science:

  • Immunology
  • Allergy Research
  • Cytokine Signaling

Background:

  • Interleukin-4 (IL-4) is a key cytokine in allergic responses.
  • Its role in the effector phase of allergy was previously unclear.

Purpose of the Study:

  • To investigate IL-4's contribution to the effector phase of allergic reactions.
  • To understand the mechanisms by which IL-4 influences anaphylaxis severity.

Main Methods:

  • Mice were pretreated with IL-4 or IL-13.
  • Anaphylaxis was induced by Fc(epsilon)RI or FcgammaRIII cross-linking.
  • The role of Interferon-gamma (IFN-gamma), T cells, B cells, common gamma chain, IL-4Ralpha, and Stat6 was assessed.

Main Results:

  • IL-4 and IL-13 pretreatment dramatically increased anaphylaxis severity.

Related Experiment Videos

  • This effect was dependent on IL-4Ralpha and Stat6 signaling.
  • Endogenous IFN-gamma inhibited IL-4's exacerbating effect.
  • IL-4 enhanced anaphylaxis synergistically with vasoactive mediators, increasing vascular permeability.
  • IL-4Ralpha signaling also amplified anaphylaxis in a nematode infection model.

    • Conclusions:

    • IL-4 plays a critical role in exacerbating the effector phase of anaphylaxis.
    • The synergy between IL-4 and vasoactive mediators contributes to allergic immunopathology.
    • This IL-4 pathway may also be involved in protective immunity against parasitic worms.