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Laryngeal stridor in multiple system atrophy.
Mika Yamaguchi1, Kimihito Arai, Masato Asahina
1Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan. fwkf4415@mb.infoweb.ne.jp
European Neurology
|March 21, 2003
Summary
Laryngeal stridor is a common early symptom in multiple system atrophy (MSA). Early stridor treatment significantly reduces mortality risk in MSA patients, making prompt diagnosis and intervention crucial.
Area of Science:
- Neurology
- Otolaryngology
Background:
- Multiple system atrophy (MSA) is a progressive neurodegenerative disorder.
- Laryngeal stridor is a potential clinical manifestation in MSA patients.
Purpose of the Study:
- To identify clinical features of laryngeal stridor in MSA patients.
- To analyze the prognostic significance of stridor in MSA.
- To evaluate the impact of stridor treatment on mortality risk.
Main Methods:
- Retrospective analysis of 104 patients diagnosed with MSA.
- Clinical data collection including onset and progression of symptoms.
- Survival analysis comparing patients with and without stridor.
- Assessment of treatment outcomes for laryngeal stridor.
Main Results:
- Laryngeal stridor was present in 36% of MSA patients, often appearing within the first four years of disease onset.
- Patients with stridor had a higher incidence of dysphagia and hoarseness, with symptom onset correlating to stridor development.
- Median survival was 8.0 years for the stridor group versus 9.0 years for the non-stridor group.
- Treatment for stridor reduced the relative mortality risk from 2.998 to 0.147.
Conclusions:
- Laryngeal stridor is a frequent and early indicator of MSA.
- Early detection and treatment of stridor are vital for improving survival rates in MSA patients.