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Related Experiment Videos

Androgen and prostatic stroma.

Yuan-Jie Niu1, Teng-Xiang Ma, Ju Zhang

  • 1Department of Prostatic Disease, Tianjin Institute of Urologial Surgery, 23 Pingjiang Road, Hexi District, Tianjin 300211, China. niuyj@public.tpt.tj.cn

Asian Journal of Andrology
|March 21, 2003
PubMed
Summary
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Androgen influences prostate stromal cell behavior, including proliferation and regression. Castration leads to stromal cell atrophy and apoptosis, with androgen receptor (AR) expression changes.

Area of Science:

  • Urology
  • Andrology
  • Cell Biology

Background:

  • The prostate gland's stromal compartment is crucial for its function and is known to be influenced by androgens.
  • Understanding the specific roles of androgens in prostatic stromal cell dynamics is essential for addressing conditions like benign prostatic hyperplasia (BPH).

Purpose of the Study:

  • To investigate the impact of androgens on the proliferation, differentiation, and regression of canine prostatic stromal cells in vivo.
  • To examine the effects of androgens on human prostatic stromal cells in vitro.

Main Methods:

  • Serum hormone levels (testosterone, estradiol) and prostate receptor expression (androgen receptor [AR], estrogen receptor [ER]) were analyzed before and after castration in dogs.
  • Histomorphology, apoptosis (TUNEL assay), and cell proliferation (MTT assay) were assessed.

Related Experiment Videos

  • In vitro studies exposed human prostatic stromal cells to dihydrotestosterone (DHT) and growth factors (bFGF, TGFbgr), analyzing cell proliferation and differentiation markers.

    • Main Results:

    • Castration rapidly decreased serum testosterone levels, leading to prostatic stromal cell atrophy and apoptosis in dogs.
    • AR expression increased early post-castration before declining, while ER expression remained stable.
    • In vitro, DHT alone had a modest effect on proliferation and smooth muscle cell (SMC) protein expression, but combinations with bFGF and TGFbgr significantly enhanced these processes.

    Conclusions:

    • The prostate gland, including its stroma, is androgen-sensitive.
    • Androgen signaling, potentially via AR, TGFbgr, and bFGF, regulates prostatic stromal cell proliferation, differentiation, and regression.