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[Prognostic value of pharmaco-EEG in depression treated with moclobemide]

Grzegorz Wiśniewski1, Janusz Jakitowicz, Zbigniew Nowicki

  • 1I Klinika Chorób Psychicznych AM w Gdańsku.

Psychiatria Polska
|March 22, 2003
PubMed

Ten women (age 41.90 +/- 5.67) with depressive episode (moderate, mild; ICD-10) were treated with moclobemide (450 mg). After 4 weeks two groups (each consists of 5 patients) with different response to the drug emerged (responders: improvement in Beck Inventory of Depression 13.6 +/- 2.9 and nonresponders: 2.0 +/- 2.4). FFT analysis of their EEG (taken before and after 4 weeks of treatment) showed some relative power differences in most bands of frequencies between groups, mostly marked for á (7-14 Hz), smaller for ä and â, but no differences for è were found. Alfa activity was relatively low after treatment in nonresponders and slightly higher in responders. However any of these results had statistical value.

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