Release of pentoxifylline from xanthan gum matrix tablets
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Updated: Sep 26, 2026

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1Pharmaceutics Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. gazayerly@hotmail.com
Abstract:
Pentoxifylline-controlled release tablets were prepared using xanthan gum. The effects of polymer concentration, rotation speed, ionic strength, and pH of the dissolution medium on the release of the water-soluble pentoxifylline were studied. The release rate decreased with increasing polymer concentration in the tablet, which was reflected in the increase in the mean dissolution time. A higher rotation speed and increased ionic strength of the dissolution medium resulted in a higher rate of drug release of xanthan-based tablets. A higher release rate of pentoxifylline was also observed using acidic dissolution medium.
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