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The calculus of immunity: quantitating antigen processing

Paul J Lehner1

  • 1Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, CB2 2XY, Cambridge, United Kingdom. pjl30@cam.ac.uk

Immunity
|March 22, 2003
PubMed

Peptide ligands destined for binding MHC class I molecules are generated by the proteasome in the cytoplasm and transported to the endoplasmic reticulum for loading onto newly synthesized class I molecules. A new study now provides a quantitative analysis of how total protein turnover in the cell relates to the efficiency of generating peptide epitopes presented by class I molecules.

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