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Antiviral flavonoids from the root bark of Morus alba L
Jiang Du1, Zhen-Dan He, Ren-Wang Jiang
1Department of Biology and Chemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China.
Phytochemistry
|March 22, 2003
Abstract:
A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods.