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Related Experiment Videos

Ras pathway signaling on endomembranes.

Trever G Bivona1, Mark R Philips

  • 1Departments of Medicine, Cell Biology and Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.

Current Opinion in Cell Biology
|March 22, 2003
PubMed
Summary

Ras proteins, crucial for cell signaling, are now known to operate not just on the plasma membrane but also on endosomes, Golgi, and endoplasmic reticulum. This compartmentalization of Ras signaling is a newly emerging area with significant biological implications.

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Area of Science:

  • Cell Biology
  • Molecular Signaling
  • Ras Biology

Background:

  • The plasma membrane was historically viewed as the primary signaling platform for Ras proteins.
  • Recent studies have expanded the known locations of Ras signaling platforms.

Purpose of the Study:

  • To review and highlight the emerging understanding of Ras signaling compartmentalization.
  • To discuss the biological significance of Ras signaling occurring at various intracellular locations.

Main Methods:

  • Literature review and synthesis of recent findings on Ras signaling localization.
  • Analysis of studies investigating Ras protein activity on endosomes, Golgi, and endoplasmic reticulum.

Main Results:

  • Ras signaling is not confined to the plasma membrane.

Related Experiment Videos

  • Endosomes, Golgi apparatus, and endoplasmic reticulum are identified as functional signaling platforms for Ras.
  • Compartmentalization of Ras signaling is a recently appreciated phenomenon.

    • Conclusions:

    • Ras signaling occurs in distinct cellular compartments beyond the plasma membrane.
    • The biological implications of this compartmentalized signaling are beginning to be understood.
    • Further research is needed to fully elucidate the functional consequences of localized Ras signaling.