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Related Experiment Videos

Functional genomic maps in Caenorhabditis elegans.

Barth D Grant1, Hilary A Wilkinson

  • 1Rutgers, State University of New Jersey, Department of Molecular Biology and Biochemistry, 604 Allison Road, Nelson Biological Laboratories, room A307, Piscataway, NJ 08854, USA. grant@biology.rutgers.edu

Current Opinion in Cell Biology
|March 22, 2003
PubMed
Summary
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Whole-genome analysis in Caenorhabditis elegans, including transcript profiling and gene-function screens, provides new insights into complex biological pathways. These genomic approaches are advancing our understanding of development and disease.

Area of Science:

  • Genomics
  • Molecular Biology
  • Developmental Biology

Background:

  • The completion of the Caenorhabditis elegans genome sequence enabled whole-genome analysis.
  • Genomic approaches are increasingly used to study complex biological systems.

Purpose of the Study:

  • To review advances in Caenorhabditis elegans genomics.
  • To highlight how these advances provide new insights into biological problems.

Main Methods:

  • Transcript profiling
  • Gene-function screens using RNA-mediated interference (RNAi)
  • Protein-interaction mapping using the yeast two-hybrid system

Main Results:

  • Genomic approaches have been applied to diverse biological problems.

Related Experiment Videos

  • New insights have been gained in areas such as tissue-specific gene expression, cell-fate specification, genome organization, DNA damage response, and early embryonic development.
  • Complex biological pathways are being probed on an unprecedented scale.

    • Conclusions:

    • Advances in Caenorhabditis elegans genomics facilitate a comprehensive understanding of biological pathways.
    • Genomic strategies are powerful tools for dissecting complex biological processes in model organisms.