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P53 expression in spontaneous and estradiol-induced endometrial hyperplasia during menopause
Hugo Maia1, Amélia Maltez, Célia Athayde
1Endoscopy Unit, Centro de Pesquisa e Assistência em Reprodução Humana - CEPARH, Rua Caetano Moura, 35, Salvador, 40210-341, Bahia, Brazil. ceparh@uol.com.br
Objective:
To determine the percentage of endometrial hyperplasia positive for p53 expression in both spontaneously occurring cases or following the use of unopposed estradiol.
Methods:
Fifty-four postmenopausal patients with endometrial hyperplasia diagnosed by endometrial biopsy and hysteroscopy were recruited to this study. Thirty-three patients had used unopposed estradiol for periods of time from 1 to 3 years. P53 expression was detected in paraffin-embedded endometrial specimens by immunohistochemical methods.
Results:
The percentage of endometrial hyperplasia positive for p53 expression was significantly greater in spontaneously occurring hyperplasia than in cases induced by the unopposed use of estradiol.
Conclusion:
Endometrial hyperplasia caused by the unopposed use of estradiol during menopause probably harbors fewer genomic errors than those cases occurring spontaneously.